Obesity & Diabetes: What’s the connection?

Clinical Trials and What You Should Know

Obesity does increase the likelihood of an individual to develop type 2 diabetes. A common understanding of medicine is that being overweight or obese is a precursor to type 2 diabetes. An obese body can create insulin, but the cells develop a resistance to it, known as prediabetes.

Your body will keep producing elevated levels of insulin as compensation for lower glucose cell absorption. This results in elevation of blood glucose levels, which greatly increases the probability of type 2 diabetes.  The good news is that obesity and type 2 diabetes are preventable with a proper diet and regular exercise.

Let’s Break Down The Information…

Obesity

How common is obesity?
A study conducted by the Centers for Disease Control and Prevention (CDC) in 2017-2018 found that 42.4% of American adults are obese.

Photo of a doctor talking to a patient

The study defines obesity as a Body Mass Index (BMI) greater than or equal to 30. The incidence of diabetes and obesity relate based on BMI and age.

As you age, the chances of becoming diabetic increase steadily. If you are obese, the risk of a diabetes diagnosis multiplies. The threat in obese women is more than double that of men in all age ranges.

Insulin Resistance

An obese body can create insulin, but the cells develop a resistance to it, known as prediabetes.

Insulin resistance is when cells in your muscles, fat, and liver do not respond well to insulin and cannot easily take up glucose from your blood. As a result, your pancreas makes more insulin to help glucose enter your cells. As long as your pancreas can make enough insulin to overcome your cells’ weak response to insulin, your blood glucose levels will stay in the healthy range.

Know Your Numbers

The accurate measure of your diabetic risk is to know your numbers. Many overweight people do not believe they are obese and are in danger of becoming diabetic. Tracking your BMI is more important than the numbers on a bathroom scale. To measure your BMI, we suggest the following link: https://www.nhlbi.nih.gov/health/educational/lose_wt/BMI/bmicalc.htm

The other number you need to know is your A1C. A1C is a measurement of your average blood glucose levels over three months. The CDC has determined that a normal A1C is below 5.7%. With a result up to 6.4%, you are considered prediabetic and diabetic above that range.

The numbers do not lie, and you can only improve what you track.

What Can I Do?

The good news is that obesity and type 2 diabetes are preventable with a proper diet and regular exercise.

According to the American Diabetes Association, physical activity promotes an increase in insulin sensitivity, which can reverse your insulin resistance, and losing approximately 10-15 pounds will impact your health significantly.

Remember, the numbers do not lie, and you can only improve what you track.

Conclusion and Closing Thoughts

Eating healthy while keeping track of your BMI and A1C can help reduce your risk of getting diabetes!

During these unprecedented times, your diabetes may have improved or worsened. At ProSciento, we will test your HbA1c at no cost as part of study screening. Schedule your appointment today!

Nutrition and Healthy Eating Information

Nutrition and Healthy Eating Information

About ProSciento’s Research Nutrition Department

A Registered Dietitian Nutritionist (RDN) is an expert in the use of food and nutrition to promote health. At ProSciento, our RDNs are responsible for providing nutritionally balanced meals for our study participant’s well-being and enjoyment while also maintaining the integrity of each research study. 

Our Research Nutrition team works hard to put together the best meals possible for you! Some studies have specific food requirements, but our meals are always meant to be nutritious while also appealing to a wide range of cultural and taste preferences. 

Upon request, meal accommodations may be made if they are within the protocol requirements and within the capabilities of the Research Nutrition Department. Possible accommodations may include vegetarian, vegan, dairy free, and gluten-free meal options. 

Celiac Sprue disease will be assessed individually by our study team prior to entry into a research study. This is to ensure that you are safe throughout your study participation.

Our Research Nutrition team creates daily menus based on the requirements for each study. Unless a study specifies otherwise, snacks may be included between meals. 

While participating in one of our studies all meals will be provided at no cost to you! If you have specific meal requirements, please let us know during your phone appointment so we may ensure you get the correct menu during your stay.

See what types of meals and foods are served during a research study: [link]

Good nutrition is about having a well-rounded diet.

There are many ways to eat healthy! Making smart food choices can help you manage your weight and lower your risk for some long-term diseases. 

Eating healthy doesn’t look the same for everyone! It’s important to find a balance that’s right for you and meets your nutritional and lifestyle needs. Restrictive diets are not always the answer. Talk to your doctor to learn more about healthy food choices that are right for you. 

Here are our top 5 healthy eating tips:

  • Pick a variety of colors for your plate.
      1. Choose brightly colored fruits and vegetables each day, orange and dark green vegetables are a great choice.
      2. Foods like dark, leafy greens, oranges, and tomatoes—even fresh herbs—are loaded with vitamins, fiber, and minerals.
  • Choose whole grain foods
      1. Replacing refined grains with whole grains is can significantly improve your health. Examples of whole grains include brown rice, 100% whole wheat bread, quinoa, barley, buckwheat, and oatmeal.
      2. Whole grains reduce risks of heart disease, stroke, cancer, diabetes, and obesity. Few foods can offer such diverse benefits.
  • Lower sodium intake
      1. Good nutrition is about balance, and that means not getting too much of certain ingredients, such as sodium (salt). Sodium increases blood pressure, which raises the risk for heart disease and stroke.
  • Avoid highly and ultra-processed foods
      1. Processed foods such as frozen meals, ready-to-eat meals, baked goods, and processed meats can be high in sugar, artificial ingredients, refined carbohydrates, and trans fats and can have negative health effects. 
      2. Read food labels. Highly and ultra-processed foods tend to have a long ingredient list with additives like artificial flavors, added sugars, stabilizers, preservatives and more. 
      3. Prepare most of your meals at home using whole or minimally processed foods. 
  • Make water your drink of choice
    1. Avoid sugary drinks and instead drink water. Sugary drinks packed with sugar provide many calories but virtually no other nutrients.
    2. Keep a reusable water bottle in your purse or car so you can fill up wherever you are going.

NASH PASS

NASH PASS

STUDY DESCRIPTON

ProSciento is currently seeking participants who may be at an increased risk for developing Non-alcoholic Fatty Liver Disease (NAFLD) or Non-alcoholic steatohepatitis (NASH). 

This is not a treatment study. There is no study drug or study device. This study will gather information about you and your health to determine your liver health status and potential eligibility for future studies relating to NAFLD/NASH. 

NAFLD (non-alcoholic fatty liver disease) /Non-alcoholic steatohepatitis (NASH) is the most common liver disease in the United States. The term NAFLD (non-alcoholic fatty liver disease) describes a range of liver disease progression. When fatty liver disease advances to a more severe level of liver injury, it is called nonalcoholic steatohepatitis (NASH) basically scaring of the liver tissue. Some risk factors for these diseases include: being overweight, Type 2 Diabetes, and elevated Lab Results for:  blood sugar, or liver enzymes, or HbA1c.

We would schedule you for a screening visit A and B (if applicable).  In the first part of the visit A, you will sign the informed consent, review inclusion/exclusion of study, medical history, demographics, blood work and a Fibroscan.  If you do not continue to visit B on same day, you will get a stipend of $25, if you do continue to Visit B, we will perform a physical exam, blood draw, smoking/alcohol history and MRI/MRE suitability criteria, you will get a stipend of $25, a total of $50 for Visit A and B. 

Based on the outcome of visit A and B, Prosciento may ask you to have a liver biopsy for a current or upcoming study. If biopsy is completed, you will receive a stipend of $300.  

If you are found to be at risk, you may be asked to participate in a sub-study that would require a liver biopsy and MRI. 

Also, you may be asked by Prosciento to have an MRI for a current or upcoming study. If MRI is completed, you will receive a stipend of $300. 

You may qualify if you are:
  • Male or Female:
    • Between the ages of 18 and 75
    • Diagnosed with Type 2 Diabetes
    • BMI higher than 25 (if not Type 2 Diabetic)
    • HbA1c higher than 5.7%
    • Elevated Liver Enzymes

Study Participants may receive:

  • Compensation is available for this study. Call us today to learn more!

Study Details

Sign Up Today

Each study has a set of criteria to determine a study participant’s eligibility. Please fill out our confidential online application. Our highly trained study participant recruiters will review your application and contact you if you may be a fit for a current or future study. Incomplete applications may not be seen—please ensure all applicable fields are filled out.



Which of the following applies to you?
Are you taking/prescribed any of the following types of medications?

I acknowledge that ProSciento may use my personal information in accordance with its Privacy Policy.

Get To Know Us

ProSciento’s clinical research facility is located 10 miles south of San Diego’s downtown area, 13 miles south of the San Diego International Airport, and 7 miles north of the US/Mexico border.

An on-site parking lot and parking garage are available and located within convenient access to public transportation. Additional transportation options may also be available at no-cost to study participants. Please ask your study participant recruiter for more information.

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855 3rd Avenue,
Suite 4400,
Chula Vista, CA 91911

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Call Us

1-866-308-7427

Hours
Monday – Friday
8:30 a.m. – 4:00 p.m.

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Opportunity for Healthy Volunteers to Participate in a Paid Research Study

Opportunity for Healthy Volunteers to Participate in a Paid Research Study

STUDY DESCRIPTON

ProSciento is currently enrolling healthy volunteers in a new research study. If you qualify, you may receive a stipend starting at $1,100 for taking a single dose of study drug or placebo along with a 4 day in house and 3 overnight stay in ProSciento’s clinical research unit located in Chula Vista, California.

You may qualify if you are:
  • 8 to 65 years old
  • A non-smoker
  • Generally healthy with no major medical conditions
  • Currently taking no prescription medications
Volunteers may receive:
  • A stipend up to $1975 for time and travel
  • Consideration for research studies at ProSciento

Study Details

Sign Up Today

Each study has a set of criteria to determine a study participant’s eligibility. Please fill out our confidential online application. Our highly trained study participant recruiters will review your application and contact you if you may be a fit for a current or future study. Incomplete applications may not be seen—please ensure all applicable fields are filled out.

Which of the following applies to you?
Are you taking/prescribed any of the following types of medications?

I acknowledge that ProSciento may use my personal information in accordance with its Privacy Policy.

Get To Know Us

ProSciento’s clinical research facility is located 10 miles south of San Diego’s downtown area, 13 miles south of the San Diego International Airport, and 7 miles north of the US/Mexico border.

An on-site parking lot and parking garage are available and located within convenient access to public transportation. Additional transportation options may also be available at no-cost to study participants. Please ask your study participant recruiter for more information.

Home Icon

Visit Us

855 3rd Avenue,
Suite 4400,
Chula Vista, CA 91911

Phone Icon

Call Us

1-866-308-7427

Hours
Monday – Friday
8:30 a.m. – 4:00 p.m.

Email Icon

Contact Us

MyProScientoStudy.com
Privacy Overview

More information about our Privacy Policy can be found here.